What is Juvenile parkinsonism?
- Juvenile parkinsonism is a rare movement disorder with symptoms that present before the age of 211
- Juvenile parkinsonism is a relatively rare syndrome1
Overlapping and differentiating symptoms of juvenile parkinsonism and AADC deficiency
- Patients with juvenile parkinsonism have prevalent dystonia and less incidence of cognitive deterioration and postural instability1
- The distinctive features of Parkinson’s disease are tremors at rest, rigidity, bradykinesia and loss of postural reflexes1
- Bradykinesia is a cardinal feature of Parkinson’s disease that overlaps with AADC deficiency1,2
- Other symptoms that appear in juvenile parkinsonism may also appear in AADC deficiency, such as dystonia, autonomic dysfunction, and cognitive delays1,2
- Thomsen TR, Rodnitzky RL. CNS Drugs. 2010;24:467–477.
- Wassenberg T, et al. Orphanet J Rare Dis. 2017;12:12.
- Hwu P, et al. EMBO Mol Med. 2021;13:e14712